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Even in healthy individuals, chronic PE (especially aerobic types) leads to redox system adaptations that decrease OS levels (Margaritelis et al., 2018

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Abbreviations HCC: Hepatocellular carcinoma ROS: Reactive oxygen species MCs: Mitochondrial carriers MPCs: Mitochondrial pyruvate carriers ABC: ATP-binding cassette transporters MCCs: Mitochondrial citrate carriers MCUs: Mitochondrial Ca 2 uniporters GSH: Glutathione TCGA: The Cancer Genome Atlas ICGC: International Cancer Genome Consortium HCCDB: Hepatocellular Carcinoma Database KM: KaplanMeier LASSO: Least absolute shrinkage and selection operator ROC: Receiver operating characteristic t-SNE: t -distributed stochastic neighbor embedding scAtlasLC: Single-cell Atlas in Liver Cancer UMAP: Uniform manifold approximation and projection siRNA: Target small interfering RNA LCMS/MS: Liquid chromatography-tandem mass spectrometry KEGG: Kyoto Encyclopedia of Genes and Genomes GO: Gene Ontology GSEA: Gene set enrichment analysis CCK8: Cell counting kit-8 MMP: Mitochondrial membrane potential mPTP: Mitochondrial permeability transition pore NAC: N-acetyl-L-cysteine References Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al

The result is a supplement architecture designed to function cohesively rather than in isolation