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In vivo evidence for the role of choline metabolism in RA comes from studies using the K/BxN serum-transfer mouse model of inflammatory arthritis, where treatment with the choline kinase alpha (ChoK) inhibitor MN58b (3 mg/kg) prevented disease onset (68)

The peptide has been studied extensively in animal models since the 1990s, with over 100 published research papers examining its effects on various tissues and conditions