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Description

Research shows that 12-hour sustained stimulation leads to marked receptor downregulation, meaning the cell actually destroys receptors rather than recycling them

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This is particularly relevant for immediate-release exenatide (Byetta), where the SmPC advises that oral contraceptives and antibiotics requiring rapid absorption should ideally be taken at least 1 hour before or 4 hours after injection

This can potentially reduce the effectiveness of oral contraceptive pills, putting users at risk of unintended pregnancy