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The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents

88 In terms of immune regulation, it has been documented that interleukin-4 (IL-4) and IL-13 inhibit the expression of GPX4 in some tissues (including heart, spleen, lung, and kidney), while the expression of ALOX15 increases, resulting in the massive production of arachidonic acid metabolites and inducing lipid peroxidation

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