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Contraindications: Hypersensitivity to empagliflozin or excipients End-stage renal disease or dialysis Use with caution in: Type 1 diabetes (risk of DKA) Frequent genital/urinary infections Low blood pressure or volume depletion Pancreatic disease Pregnancy (avoid 2nd/3rd trimester) or breastfeeding Onset of action Blood sugar reduction begins within 12 weeks

In states requiring collaborative agreements, a supervising physician relationship is necessary but can often be arranged without requiring the physician to be on-site daily

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Studies also indicate that semaglutide does not affect the efficacy of antidepressants