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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For

Some research has suggested potential mechanisms by which severe nutritional deficiencies might theoretically affect hair pigmentation, including: Oxidative stress affecting melanocyte function Impaired cellular metabolism within hair follicles Disrupted synthesis of compounds necessary for melanin production A small number of case reports have documented instances where correcting severe B12 deficiency appeared to coincide with some hair colour restoration, though these remain anecdotal and do not establish causality or predict reversibility