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The expression of pro-ferroptosis genes was also found to be downregulated in the epidermis of mutant mice, and the expression of ferroptosis-suppressing genes such as Gpx4 and Slc7a11 was upregulated

These come from the needling, not from AHK-Cu

[DOI] [PubMed] [Google Scholar] 50.Ogunkolade B.W., Boucher B.J., Prahl J.M., Bustin S.A., Burrin J.M., Noonan K., North B.V., Mannan N., McDermott M.F., DeLuca H.F., et al

[3] For confirmed deficiency with neurological involvement: 1 mg IM on alternate days until no further improvement, then 1 mg every two months urgent initiation is essential to prevent irreversible nerve damage