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Indeed, the UPR has been associated with obesity-related metabolic disorders, insulin resistance, and inflammatory responses

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Abbreviations ALI: Acute lung injury ALT: Alanine aminotransferase AST: Aspartate aminotransferase BALF: Bronchoalveolar lavage fluid BiMP NZs: Bimetallic manganese-platinum nanozymes CK: Creatine kinase COPD: Chronic obstructive pulmonary disease CREA: Creatinine CS: Cigarette smoking CSE: Cigarette smoke extract DEGs: Differentially expressed genes DLS: Dynamic light scattering ESR: Electron spin resonance FEV 0.05s : Forced expiratory volume in 0.05 s FVC: Forced vital capacity GSH/GSSG: The ratio of reduced glutathione to oxidized glutathione HO: Hydrogen peroxide LDH: Lactate dehydrogenase LPS: Lipopolysaccharide MDA: Malondialdehyde MLI: Mean linear intercept MM-BiMP NZs: Macrophage membrane-biomimetic bimetallic Mn-Pt nanozymes Mn-Pt: Manganese-platinum NAC: N-acetylcysteine O: Singlet oxygen O: Superoxide anions OH: Hydroxyl radicals PCO: Partial pressure of carbon dioxide PO: Partial pressure of oxygen ROS: Reactive oxygen species TEM: Transmission electron microscopy T-SOD: Total superoxide dismutase XPS: X-ray photoelectron spectroscopy XRD: X-ray diffraction References de Oca MM, Perez-Padilla R, Celli B, Aaron SD, Wehrmeister FC, Amaral AFS, et al