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In human cholangiocarcinoma cells (TFK-1, SZ-1), bromelain (and papain) blocked NF-B/AMPK signalling, inducing cytotoxic effects through the activation of apoptosis in both cell lines after 48h of treatment (94)

Methylation support may include active B vitamins, magnesium, choline, trimethylglycine (TMG), methionine, zinc, and SAMe

Neurology 69 , S14S22 (2007)

It is important to note that while these mechanisms have been suggested based on experimental studies, further research is needed to fully elucidate how BPC-157 works and to determine its specific effects in different tissues lab animals and human subjects under clinical conditions