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A systematic review found no acute toxicity in animals and no adverse events across various doses

W.SampathT

Although numerous large-scale clinical studies have fully confirmed that these new drugs can rapidly and persistently alleviate RA symptoms, their safety has always been controversial, particularly regarding potential risks such as venous thromboembolism and infection [40, 41]

In mice, no impact of a CR diet was observed on the number of CD4 + or CD8 + cells in the TME