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While GLP-1 and GIP receptor activation primarily reduce energy intake through appetite suppression and delayed gastric emptying, glucagon receptor activation continues to drive energy expenditure through thermogenesis and hepatic fat oxidation regardless of whether caloric intake has already decreased

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These receptor agonists are recognized for their cardioprotective properties and have been approved by the FDA to lower the risk of major adverse cardiovascular events in individuals who are overweight or obese with cardiovascular disease

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