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Journal of Holistic Integrative Pharmacy

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By triggering an imbalance in redox homeostasis, mitochondrial dysfunction not only impairs electron transport chain activity but also disrupts the dynamic balance between organelles, leading to ultrastructural abnormalities (e.g., mitochondrial cristae rupture, endoplasmic reticulum vesiculation) and oxidative damage to key biomolecules in oocytes, which, in turn, significantly reduces the developmental potential of oocytes and the cytoplasm of oocytes