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Acknowledgements We thank Professor Michelle Bader in Max Planck Institute for Molecular Genetics (Berlin, Germany) for presenting the TPH1 knockout mice

Early work in liver research indicates a link in the regulation between gastrointestinal hormones and liver autophagy (Ueno and Komatsu, 2017)

If you are experiencing such problems, in the first instance you should see your GP who will undertake a blood test, review your symptoms, and diagnose any deficiency, alongside any need for dietary changes, oral supplementation, or prescribed injections of vitamin B12