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however, the half-life in epithelial lining fluid is much longer, suggesting independence of respiratory epithelial lining fluid and plasma with regard to GSH metabolism

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Preclinical studies suggest that GLP-1 signaling may reduce oxidative stress markers and modulate pathways associated with cellular stress responses in vascular and metabolic tissues [13,14]

Tirzepatide has demonstrated superior efficacy in both weight loss and blood glucose control compared to semaglutide (Aronne et al., 2025), highlighting the therapeutic potential of multi-agonist strategies