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This differential may be explained by the fact that the Fang study was based on self-reported data, which may be susceptible to inaccuracies or low response rates, whereas our study relied on claims data

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The review considers the repurposing of GLP-1Ras from the perspective of integrative physiology, summarizes modern concepts about the mechanisms of action of GLP-1RAs according to the results of experimental studies and presents current clinical data on the use of GLP-1RAs in patients with brain diseases

Future studies may explore how sequence variations impact the role of GPER in disease