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Clinical trial data suggests headaches may occur somewhat more frequently with semaglutide than with placebo, though the difference varies across studies

Improper storage can reduce the medicines quality

Ingredients Glucose syrup, white chocolate (20%) [sugar, cocoa butter, whole milk powder, emulsifier (lecithin (soy)), flavouring], whole milk powder, milk protein (10%), invert sugar syrup, fruit preparation [sugar, raspberry and cherry juice from fruit juice concentrate, raspberry pulp (1%), fructose syrup, concentconcentconcentconcentconcentconcentconcentlactose (milk), palm kernel fat, natural flavour, gelling agent (pectins), antioxidant (ascorbic acid)], marzipan [sugar, almonds, water, humectant (sorbitol, invertase), invert sugar syrup, glucose syrup], whey protein (milk) (4%), oligofructose, humectant (glycerine), sweet

Get any of those rules wrong and the protein unfolds, loses bioactivity, and becomes useless (and in rare cases, immunogenic)