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A dual GLP-1-estrogen conjugate (GE) designed to selectively deliver estrogen to GLP-1R + cells induced substantial weight loss in mice without evidence of systemic estrogenic effects, as assessed by uterine weight and growth of estrogen-dependent breast cancer xenografts (Sachs et al., 2020)

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Discussion Cellular senescence, triggered by diverse external and internal stressors, serves as a protective response that prevents the proliferation of impaired cells, thereby conferring resistance to cancer 45,468

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