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Notably, a hyposialylated pro-proteinuric form of ANGPTL4 has been identified as a crucial contributor to fibrosis within diabetic kidneys

Fernandez-Real JM, Broch M, Vendrell J, Ricart W

The DAPA-CKD trial, for instance, demonstrated that dapagliflozin significantly reduced the risk of a composite outcome of sustained eGFR decline, end-stage kidney disease, or renal/cardiovascular death by 39% in patients with chronic kidney disease, with consistent benefits observed in participants with and without type 2 diabetes (Savedchuk et al., 2023)

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