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GAT-1 maintains the homeostasis of inhibitory neuronal microcircuits, and its functional or expression abnormalities are closely associated with the development of various neurological disorders, including autism, schizophrenia, and epilepsy (42, 43)

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Semaglutide and tirzepatide also reduce liver fat, with tirzepatide generally showing greater reductions than semaglutide, but neither approaches the 80%+ reductions seen with retatrutide