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Trelagliptin (syr-472, zafatek), novel once-weekly treatment for type 2 diabetes, inhibits dipeptidyl peptidase-4 (dpp-4) via a non-covalent mechanism

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It contains an absorption enhancer (SNAC) that allows the medication to be absorbed through the stomach lining, but requires specific administration instructions including taking it on an empty stomach with limited water and waiting 30 minutes before eating or taking other medications

An expert will have a better idea of where the gallstone is located