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The intrinsic factor-mediated pathway operates regardless of food presence, and the passive diffusion mechanism (responsible for absorbing about 1% of high doses) similarly functions independently of meals

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Pharmacol Res 91:4756 Ikeda S, Matsushima S, Okabe K, Ikeda M, Ishikita A, Tadokoro T, Enzan N, Yamamoto T, Sada M, Deguchi H, Morimoto S (2019) Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-B pathway