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In embryonic Drosophila , the activation of DUOX and subsequent H 2 O 2 production was shown to be triggered by wound-induced calcium (Ca 2+ ) flashes, where Ca 2+ binds to an EF hand Ca 2+ -binding motif of DUOX 72
[54] [55] Example 4: Preparation of L-carnitine (6) [56] 37 mL (0.156 mole) of an aqueous 30 wt/% trimethylamine solution was placed in 10 g (0.06 mole) of ethyl (R)-4-chloro-3-hydroxybutyrate, and the mixture was heated and stirred at a temperature of 80 to 90 0 C for 3 hours
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