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With significant or rapid weight loss, particularly when driven by GLP-1 drugs, several mechanisms converge: Loss of underlying fat volume removes structural support Collagen and elastin fibres become stretched and fragmented Speed of weight loss outpaces skin contraction While some rebound occurs naturally, significant laxity can be permanent, especially after large weight reductions

In studies of the effects of GLP-1, researchers estimate that 25 to 39 percent of the weight people lose on the drugs is muscle

In mid to late 2025, around 12.4% of US adults reported taking a GLP-1 medicine specifically for weight loss, up from 5.8% in February 2024, according to Gallup survey data of more than 15,000 adults

Persistent constipation, dizziness, vomiting, dehydration, severe abdominal pain, or fainting should always be discussed with a qualified healthcare provider