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Healthcare providers recommend intentional water consumption and electrolyte awareness, particularly during the dose-escalation phase

Compounds used for in vivo experiments were further purified by size exclusion chromatography using a HiLoad Superdex 200 pg column (GE Healthcare) and further characterised for endotoxin level using the LAL Kinetic-QCL (Lonza) and integrity by LC/MS using an Acquity UPLC system coupled to a Synapt G1 mass spectrometer (Waters)

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