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Linkova NS, Drobintseva AO, Orlova OA, Kovtun NV, Polyakova VO, Klinova SV, Mikhailova ON, Kvetnoy IM, Khavinson VKh

doi: 10.1016/j.aqrep.2023.101487 54 WuX.LiP.MiY

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Based on this review, we conclude that the perceived contradictory roles of growth hormone and insulin-like growth factor-1 in the genesis of the aging phenotype should not be interpreted as a controversy on whether growth hormone or insulin-like growth factor-1 increases or decreases life span but rather as an opportunity to explore the complex roles of these hormones during specific stages of the life span.