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In response to external stimuli (e.g., hypoxia, ischemia, drug-induced injury), mTORC1 promotes the translation of HIF-1, thereby driving a metabolic shift from oxidative phosphorylation to glycolysis (Wang et al., 2020)

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A randomized, double-blind, placebo-controlled, phase III study to assess efficacy and safety of weekly farletuzumab in combination with carboplatin and taxane in patients with ovarian cancer in first platinum-sensitive relapse