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32 Redox functions of NAD + When initially discovered, the function of NAD + was attributed to the universal electron transporter in redox reactions for obtaining energy in catabolic processes

The Phase 2 trial data confirms this: the 1mg dose group achieved only 8.7% weight loss at 48 weeks, indicating that low doses produce modest effects that accumulate slowly

The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017