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A research article about the doseresponse effects of survodutide, a dual agonist of the subcutaneous glucagon receptor and glucagon-like peptide- 1 receptor, on bodyweight loss and HbA1c levels

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The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes

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