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A meta-analysis of 15 studies and 15,498 subjects found an increased relative risk of HTN with higher circulating TMAO levels (1.14, 95% CI 1.081.20), and although the RR is relatively small for such a large sample size, this relationship was dose-dependent with a 1.014% increase in HTN risk for every increase of TMAO level by 1 mol/L [70]

The full data set will be available later this year and will provide further insights to help optimize the dosing regimens in future trials. References 1

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