switch to tirzepatide from semaglutide Semaglutide: Safety Guide – PlexusDx Transitioning Treatments: What to Expect

Our patients arrive already on them, and we're left interpreting mood changes, anhedonia, and restrictive eating patterns without much guidance on what's drug, what's illness, and what's neither

Mata P, Garrido JA, Ordovas JM, Blazquez E, Alvarez-Sala LA, Rubio MJ, Alonso R, de Oya M

Lipo C may improve overall metabolic efficiency and energy, making it a useful complement for some patients, but clinical evidence for a synergistic weight loss effect is limited

Importantly, semaglutidetreated patients experienced sustained weight loss (mean ~10.2% vs 1.5% at 208 weeks) and improvements in waist circumference and waisttoheight ratio, anthropometric changes that track with cardiometabolic risk reduction