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An equally important unanswered question pertains to the mechanism that integrates TBC1D9B into the cellular network of ARL8B effectors and their regulators, e.g., PLEKHM2/SKIP 10 , KIF1A 19,20 , HOPS 21 , or RUFY1 or RUFY3 and 4 11,24 to exhibit contextual specificity of protein interactions at lysosomes and, possibly, other sites of ARL8B activity, such as recycling endosomes 23

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The key is understanding that successful management during this time requires a comprehensive approach