retatrutide phase 2 trial obesity nejm 2023

retatrutide phase 2 trial obesity nejm 2023 Retatrutide, a TRIPLE agonist (GLP1, GIP, glucagon), just released results demonstrating 25% weight loss in half of people with #obesity. This amount of weight loss has not been accomplished Triple–Hormone-Receptor Agonist Retatrutide for Obesity

Name: retatrutide phase 2 trial obesity nejm 2023 Retatrutide, a TRIPLE agonist (GLP1, GIP, glucagon), just released results demonstrating 25% weight loss in half of people with #obesity. This amount of weight loss has not been accomplished Triple–Hormone-Receptor Agonist Retatrutide for Obesity
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Description

Effect of Incretin-Based Therapies on Blood Pressure: A Systematic Review and Meta-Analysis

13.7% average weight loss

When tested in clinical trials, this drug was found to be highly effective

The model of the open state conformation was based on the cryo-EM structure of GLP-1GLP-1RGs (PDB: 5VAI) and the Fab7F38ECD complex of the Fab7F38GLP-1R crystal structure presented here, which were superimposed on their ECDs using PyMOL