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Experiments show that feeding mice high-fat diets disrupts their food intake regulation and makes them develop obesity (Ikemoto et al., 1996), but also changes certain structures in the brains of their offspring (Lippert et al., 2020)

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The HCV protease NS3/4A can also cleave some cellular targets involved in the innate immunity, such as MAVS (an antiviral signaling protein), which can indirectly activate the nuclear factor-kappa B (NF-B) and the IFN regulatory factor 3 to induce type I interferon[60,61]

However, the AngII/AT1 receptor system influences multiple functions beyond blood pressure, including body water balance, control of vasopressin and oxytocin release and sexual reproduction and behavior, thus undesirable drug-induced effects are possible