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Jia R, Yuan X, Zhang X, Song P, Han S, Wang S, Li Y, Zhang S et al (2023) Oxidative stress impairs cognitive function by affecting hippocampal fimbria volume in drug-naive, first-episode schizophrenia

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The brain must clear out the metabolic byproducts and wastes from each day through the lymph system and into the venous drainage, much like flushing a toilet, and this process requires both sleep and lying down, which maximizes both lymphatic and venous outflow