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They are considered the twin epidemics of the 21st century
It means the recommendations in this guide are built on mechanistic reasoning and clinical experience rather than dedicated trial data
12 Building on these results, the SCALE Maintenance trial demonstrated that the combination of liraglutide 3.0 mg per day and lifestyle intervention significantly improved weight maintenance at 56 weeks when compared with controls (who received placebo and lifestyle intervention) in overweight and obese individuals who had already lost at least 5% of initial body weight during a low-calorie diet prior to randomization
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