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282,283 These cells accumulate in the synovial membrane and subchondral bone, releasing pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which promote the degradation of joint cartilage and the inflammatory response
139 Exosomes derived from ferroptosis-induced breast cancer cells (Fe-Exos) markedly reduce the expression of macrophages M2 markers Arg-1 and CD206
Its large molecular size prevents significant systemic absorption, making it safe for pregnancy use
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