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33 This article updates previous articles on this topic by Langan and Zawistoski, 4 and by Oh and Brown

Key genes modulated by GHK-Cu include: Genes encoding growth factors (FGF, VEGF, TGF-) Collagen and extracellular matrix proteins (COL1A1, COL3A1, ELN) Anti-inflammatory and antioxidant enzymes (SOD, catalase) Cell adhesion and communication molecules Collagen & Extracellular Matrix Synthesis Collagen synthesis is fundamental to GHK-Cu's regenerative effects