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Carnitine can increase TMAO (a gut-derived metabolite), especially in omnivores, but whether that changes outcomes with supplementation is unsettled

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For example, in studies where skin fibroblasts were treated with GHK-Cu, there was increased expression of extracellular matrix genes and antioxidant enzymes

343 According to a 2020 systematic review and meta-analysis that included 60 randomized controlled trials with a total of 4,129 patients, omega-3 fatty acid supplementation appeared to decrease the incidence of cardiovascular death by 55% in CKD patients on hemodialysis, though it did not appear to reduce mortality overall