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Semaglutide and tirzepatide trials demonstrate 5-22% body weight reduction in sedentary or minimally active participants, though individual results vary based on metabolic factors, adherence, and baseline health status

10.3389/fphar.2023.1205207 Front

Real-World Evidence of GLP-1 RA Therapy in T2D A substantial body of data in real-world settings supports the efficacy and safety of GLP-1 RAs evidenced from the randomised controlled trials (RCTs)

The microbiota and it's correlation with metabolites in the gut of mice with nonalcoholic fatty liver disease