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Moreover, in MAR709 experiments, the attachment of exenatide (2939) has a limited positive effect on GLP-1 activity (EC 50 : 0.022 nM0.020 nM)
Interest in this possibility was rekindled by John Dupr, a Canadian endocrinologist at St Thomas' Hospital in London
In addition to the metabolic benefits, such as normalizing glucose and insulin, a 2020 study published in Molecular and Cellular Endocrinology suggests that Metformin may also decrease oxidative stress and inflammation