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[5] SURMOUNT-4 ran the same experiment with tirzepatide and got the same answer, a 21% average loss largely surrendered within a year of stopping

Intrinsic Factor replacement therapy can cause side effects such as: Pain or swelling at the injection site Allergic reactions to the synthetic intrinsic factor The adverse effects may be transient in some situations and get better with time, but they may also be severe in other circumstances and need medical treatment