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1 Introduction Epilepsy is a common disorder of the central nervous system (CNS), characterized not only by recurrent epileptic discharges but also by frequent and severe neuropsychiatric comorbidities, with depression being the most prevalent (Alhashimi et al., 2022)

[19] The enzymes that use B 12 as a built-in cofactor are methylmalonyl-CoA mutase (PDB 4REQ [43] ) and methionine synthase (PDB 1Q8J)

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