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14 A 2017 meta-analysis of 52 randomized, controlled trials that evaluated DPP-4 inhibitors' effects on beta-cell function found that, in monotherapy studies, all agents except linagliptin resulted in improvements in cell function

Injectable tirzepatide achieves peak serum levels in 872 hours with consistent weekly dosing, while oral formulations require enteric protection and absorption enhancers to overcome gastric degradation, resulting in lower bioavailability and variable individual response patterns

FDA United States Food and Drug Administration, EMA European Medicines Agency T2DM Type 2 Diabetes Mellitus, MASH metabolic-associated steatohepatitis, CKD Chronic kidney disease, MACE Major adverse cardiovascular events Are There Specific Patient Populations Who Might Benefit Most from GLP-Agonists