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Endogenous timing remains regulated by hypothalamic GHRH and somatostatin oscillations, preserving physiologic rhythm structure in experimental models

Differences between GLP-1R agonists GLP-1R agonists already in the market and others in development present the same mode of action and, having the same pleiotropic effects of native GLP-1, the differences in clinical profiles between them are related to differences in pharmacokinetics, structure and size of each formulation

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The perforated patch pipette solution contained (mmol/l): 76 K 2 SO 4 , 10 KCl, 10 NaCl, 55 sucrose, 10 HEPES, 1 MgCl 2 (pH 7.2), to which amphotericin B was added to a final concentration of 200 g/ml