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In the multiplexed tandem mass tag (TMT) preparation (Thermo, A34808), in the 11 th channel (TMT11-131C) we included an untreated H23 lysate mix, which was not subjected to temperature challenge or ultracentrifugation, in an effort to enhance discovery of underrepresented peptides

AD pathology is higher in cognitively normal older adults who have symptoms that are co-morbid with depression, including anxiety (A), worry (A), apathy (A and Tau) and loneliness (Tau) [324,325,326,327,328]

Inhibiting Tyrosinase Activity Some antioxidants, such as vitamin B, C and glutathione, inhibit tyrosinase, the enzyme responsible for melanin synthesis

Furthermore, after in vitro ferroptosis inducer ferric ammonium citrate (FAC) intervention, mammalian oocytes experienced increases in ROS and autophagy-related protein LC3 and mitochondrial dysfunction