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ANTIDEPRESSANT WITHDRAWAL SYMPTOMS PHYSICAL SYMPTOMS Gastrointestinal: abdominal pain, diarrhoea, nausea, vomiting Influenza-like: fatigue, headache, muscle pain, weakness, sweating, chills, palpitations Sleep disturbance: insomnia, vivid dreams, nightmares Sensory disturbances: dizziness, light-headedness, vertigo, pins and needles, electric shock sensations Motor disorders: tremor, loss of balance, muscle stiffness, abnormal movements PSYCHOLOGICAL SYMPTOMS Anxiety, agitation Crying spells Irritability Overactivity Aggression Depersonalisation Memory Problems Confusion Lowered mood Beta-blockers In a few cases, severe palpitations, muscle tremors or motor jerks develop during benzodiazepine withdrawal and hinder progress

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Peptide Therapeutics: Current Status and Future Directions