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Acknowledgements The authors would like to thank the Deanship of Scientific Research at King Faisal University in Kingdom of Saudi Arabia for funding for this research and the efforts made in completed.

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Our in vitro studies on primary peritoneal macrophages from Gstp / mice and wild-type mice, and cell lines of RAW264.7 and THP-1 indicated that GSTP inhibited LPS-induced HMGB1 release through preventing its translocation from the nucleus to cytoplasm

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