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Thirdly, the current preclinical studies lack standardized outcome measures, meaning more systematic in vivo studies are required to validate the efficacy and safety of mitochondria-targeted ferroptosis modulators

PMID: 28809450

doi: 10.1016/j.cmet.2020.06.010

These transgenerational effects operate primarily through epigenetic modifications, germline transmission of molecular alterations, and persistent fertility impairments that challenge traditional concepts of toxicological risk assessment (84)