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To overcome these limitations, in this study, we describe the rational design, synthesis, and in-depth biological assessment of ruthenium (Ru)-containing nanoreactors for the catalytic oxidation of GSH to GSSG in hypoxic osteosarcoma

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Healthcare professionals typically initiate treatment at a lower dose (0.25 mg weekly), which is an initiation dose only and not intended for glycaemic control, and gradually increase to therapeutic levels (0.5 mg or 1 mg weekly) to minimise these symptoms whilst allowing the body to adapt to the medication's effects on the digestive system

The 7.5 mg dose often represents a turning point, producing peak weight loss of 5-7 lbs per month during months 3-6