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It is related to a deficiency of the vitamins B12 and B6

Despite lifetime exposure to a wide variety of toxic chemicals, the presence of multiple GST classes with diverse substrate specificities facilitates an organism adaptation to adverse environments

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Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I: Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM